PPARγ agonist-induced alterations in Δ6-desaturase and stearoyl-CoA desaturase 1: Role of MEK/ERK1/2 pathway
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Investigation of (Stearoyl-CoA Desaturase 1) SCD1 Gene Polymorphism in Khuzestan Buffalo Population Using PCR-RFLPMethod
Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA). A number of studies support the hypothesis that SCD gene regulation and polymorphism may affect fatty acid composition and fat quality in meat and milk. Single nucleotide polymorphisms in the coding region of the bovine stearoyl-CoA desaturase gene have been predicted to result in ...
متن کامل1 MEMBRANE TOPOLOGY OF MOUSE STEAROYL - COA DESATURASE 1 Weng
MEMBRANE TOPOLOGY OF MOUSE STEAROYL-COA DESATURASE 1 Weng Chi Man*, Makoto Miyazaki*, Kiki Chu*, and James M. Ntambi* From the Departments of *Biochemistry and ¶Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706 Running Title: Mouse SCD1 Topology Address correspondence to: James M. Ntambi, Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madi...
متن کاملTargeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression
Stearoyl-CoA desaturase 1 (SCD1) is an established molecular target in many primary tumors including breast, lung, pancreatic, colon and hepatocellular carcinomas. However, its potential role in supporting endometrial cancer growth and progression has not yet been determined. In this study, we evaluated the value of SCD1 as a candidate therapeutic target in human endometrial cancer. Compared wi...
متن کاملRole of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism.
Stearoyl-CoA desaturase-1 (SCD1) converts saturated fatty acids (SFA) into monounsaturated fatty acids and is necessary for proper liver, adipose tissue, and skeletal muscle lipid metabolism. While there is a wealth of information regarding SCD1 expression in the liver, research on its effect in skeletal muscle is scarce. Furthermore, the majority of information about its role is derived from g...
متن کاملCritical role of miR-125b in lipogenesis by targeting stearoyl-CoA desaturase-1 (SCD-1).
Alteration of gene expression tightly regulates lipogenesis. Stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in lipogenesis, catalyzes the conversion of SFA to MUFA, and inhibition of its activity impairs lipid synthesis. As posttranscriptional regulators, microRNAs are involved in many pathways of lipid metabolism; however, their effect on SCD-1 has not been reported. In this study, miR-125b w...
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ژورنال
عنوان ژورنال: World Journal of Hepatology
سال: 2013
ISSN: 1948-5182
DOI: 10.4254/wjh.v5.i4.220